Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EW6H
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| Former ID |
DIB020245
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| Drug Name |
LTC4
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| Synonyms |
leukotriene C4
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C30H47N3O9S
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| Canonical SMILES |
CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
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| InChI |
1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
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| InChIKey |
GWNVDXQDILPJIG-NXOLIXFESA-N
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| CAS Number |
CAS 72025-60-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5241, 4266071, 7978470, 8144736, 8616294, 26756768, 39289599, 47439963, 50111412, 53787291, 57357762, 76781864, 92126168, 103591345, 113853360, 126523876, 127302679, 127302680, 127302681, 127302682, 127302683, 127302684, 127302685, 135651512, 137005676, 137240026, 138355248, 179293089, 184584916, 198947983, 237822003, 250135036, 252455506, 252467942
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| ChEBI ID |
CHEBI:16978
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukotriene CysLT1 receptor (CYSLTR1) | Target Info | Agonist | [2] |
| Leukotriene CysLT2 receptor (CYSLTR2) | Target Info | Agonist | [3] | |
| Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) | Target Info | Agonist | [4] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| IL3 Signaling Pathway | ||||
| Pathway Interaction Database | Endothelins | |||
| Reactome | Leukotriene receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3354). | |||
| REF 2 | Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93. | |||
| REF 3 | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8. | |||
| REF 4 | The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. | |||
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