Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EV8E
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| Former ID |
DAP001269
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| Drug Name |
Econazole
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| Synonyms |
Ecostatin; Palavale; Pevaryl; Ecostatin Vaginal Ovules; Ecostatin cream; Spectazole cream; SQ 13050; Ecostatin (TN); Gyno-Pevaryl 150; Gyno-pevaryl; Pevaryl (TN); Spectazole (TN); Econazole (USAN/INN); 1-[2,4-Dichloro-.beta.-[(p-chlorobenzyl)oxy]phenethyl]imidazole; 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
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| Drug Type |
Small molecular drug
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| Indication | Cutaneous candidiasis [ICD-11: 1F23.14] | Approved | [1] | |
| Tinea corporis [ICD-11: 1F28.Y] | Approved | [1] | ||
| Tinea cruris [ICD-11: 1F28.3; ICD-10: B35.6] | Approved | [1] | ||
| Tinea pedis [ICD-11: 1F28.2; ICD-10: B35.3] | Approved | [1] | ||
| Tinea versicolor [ICD-11: 1F2D.0; ICD-10: B36.0] | Approved | [1] | ||
| Therapeutic Class |
Antifungal Agents
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| Company |
Merz Pharmaceuticals Llc
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H15Cl3N2O
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| Canonical SMILES |
C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
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| InChI |
1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
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| InChIKey |
LEZWWPYKPKIXLL-UHFFFAOYSA-N
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| CAS Number |
CAS 27220-47-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10268, 448079, 603851, 7440588, 7979146, 8152035, 11335288, 11360527, 11364117, 11366679, 11369241, 11372592, 11373971, 11377403, 11405957, 11406340, 11461499, 11466332, 11467452, 11485314, 11486223, 11489255, 11491282, 11492261, 11495037, 14829428, 29222340, 46508881, 47205924, 47440102, 47515167, 47736313, 48034959, 48184847, 48334335, 48334336, 49698924, 50077661, 53787959, 56312807, 56313676, 56314323, 57321659, 79476142, 85173352, 85240399, 85788404, 92711383, 103212333, 104024743
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| ChEBI ID |
CHEBI:82873
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| ADReCS Drug ID | BADD_D00740 ; BADD_D00741 | |||
| SuperDrug ATC ID |
D01AC03; G01AF05
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| SuperDrug CAS ID |
cas=027220479
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homolo... Antimicrob Agents Chemother. 2008 Oct;52(10):3597-603. | |||
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