Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EK1C
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| Former ID |
DIB015750
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| Drug Name |
PHE-377
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| Synonyms |
V 377; 2-(Diisopropylamino)-2',6'-acetoxylidide, hydrochloride; 2',6'-ACETOXYLIDIDE, 2-(DIISOPROPYLAMINO)-, HYDROCHLORIDE; AC1Q1RXG; AC1L1G06; LS-13907; 77966-84-8; [2-(2,6-dimethylanilino)-2-oxoethyl]-di(propan-2-yl)azanium chloride; [2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]-di(propan-2-yl)azanium chloride
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Phase 1 | [1] | |
| Company |
PharmEste SRL
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| Structure |
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Download2D MOL |
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| Formula |
C16H27ClN2O
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| Canonical SMILES |
CC1=C(C(=CC=C1)C)NC(=O)C[NH+](C(C)C)C(C)C.[Cl-]
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| InChI |
1S/C16H26N2O.ClH/c1-11(2)18(12(3)4)10-15(19)17-16-13(5)8-7-9-14(16)6;/h7-9,11-12H,10H2,1-6H3,(H,17,19);1H
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| InChIKey |
OJTPHJHZGWBMET-UHFFFAOYSA-N
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| CAS Number |
CAS 77966-84-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031648) | |||
| REF 2 | Clinical pipeline report, company report or official report of Pharmeste. | |||
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