Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E9SR
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| Former ID |
DIB018311
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| Drug Name |
[3H]JNJ 7777120
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| Synonyms |
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine; JNJ-7777120; 459168-41-3; JNJ7777120; JNJ 7777120; UNII-4H1AU2V37X; HUQJRYMLJBBEDO-UHFFFAOYSA-N; 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine; 4H1AU2V37X; CHEMBL129198; 1-[(5-CHLORO-1H-INDOL-2-YL)CARBONYL]-4-METHYL-PIPERAZINE; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine; (5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; (5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; METHANONE, (5-CHLORO-1H-INDOL-2-YL)(4-METHYL-1-PIPERAZINYL)-; STK175446; [3H]-JNJ7777120; [3H]-JNJ7777120
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| Drug Type |
Small molecular drug
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H16ClN3O
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| Canonical SMILES |
CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl
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| InChI |
1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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| InChIKey |
HUQJRYMLJBBEDO-UHFFFAOYSA-N
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| CAS Number |
CAS 459168-41-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7208642, 8472987, 14799535, 29217572, 39075314, 49846380, 50075249, 57357288, 57818501, 61262560, 78047416, 81123443, 85083127, 89501661, 103361356, 113628387, 125299313, 125333903, 131693053, 134343094, 135262061, 135650446, 135651168, 135697623, 137014298, 143295275, 162009834, 162012011, 162248412, 163123369, 167272760, 174529437, 184629548, 187071988, 198975186, 204370503, 223835200, 226546411, 246996609, 249776624, 250134239, 251970998, 252157719, 252160038, 252450534, 252472158
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H4 receptor (H4R) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCR ligand binding | |||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1278). | |||
| REF 2 | A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. | |||
| REF 3 | Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. | |||
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