Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E9EE
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| Former ID |
DCL000232
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| Drug Name |
SR 144190
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| Synonyms |
SR-144190; 3-(1-(2-(4-benzoyl-2-(3,4-difluorophenyl)morpholin-2-yl)ethyl)-4-phenylpiperidin-4-yl)-1-dimethylurea
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| Drug Type |
Small molecular drug
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| Indication | Acute or chronic pain [ICD-11: MG30-MG31] | Discontinued in Phase 1 | [1] | |
| Anxiety disorder [ICD-11: 6B00-6B0Z] | Discontinued in Phase 1 | [1] | ||
| Depression [ICD-11: 6A70-6A7Z] | Discontinued in Phase 1 | [1] | ||
| Urinary incontinence [ICD-11: MF50.2] | Discontinued in Phase 1 | [1] | ||
| Therapeutic Class |
Analgesics
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| Company |
Sanofi-aventis
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| Structure |
 |
Download2D MOL |
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| Formula |
C33H38F2N4O3
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| Canonical SMILES |
CN(C)C(=O)NC1(CCN(CC1)CCC2(CN(CCO2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)F)F)C5=CC=CC=C5
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| InChI |
1S/C33H38F2N4O3/c1-37(2)31(41)36-32(26-11-7-4-8-12-26)15-18-38(19-16-32)20-17-33(27-13-14-28(34)29(35)23-27)24-39(21-22-42-33)30(40)25-9-5-3-6-10-25/h3-14,23H,15-22,24H2,1-2H3,(H,36,41)
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| InChIKey |
QNLIUVLFRVYNCV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Substance-K receptor (TACR2) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008589) | |||
| REF 2 | Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract. Am J Vet Res. 2004 Jul;65(7):984-91. | |||
| REF 3 | Antagonists at the neurokinin receptors--recent patent literature. IDrugs. 2003 Aug;6(8):758-72. | |||
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