Drug Information
Drug General Information | Top | |||
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Drug ID |
D0E7XR
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Former ID |
DNC009325
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Drug Name |
KNI-10283
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C36H44N4O6S
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Canonical SMILES |
CC1=CC(=CC(=C1OCC(=O)NC(CC2=CC=CC=C2)C(C(=O)N3CSC(C3C(=O)NC4C(CC5=CC=CC=C45)O)(C)C)O)C)NC
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InChI |
1S/C36H44N4O6S/c1-21-15-25(37-5)16-22(2)32(21)46-19-29(42)38-27(17-23-11-7-6-8-12-23)31(43)35(45)40-20-47-36(3,4)33(40)34(44)39-30-26-14-10-9-13-24(26)18-28(30)41/h6-16,27-28,30-31,33,37,41,43H,17-20H2,1-5H3,(H,38,42)(H,39,44)/t27-,28+,30-,31-,33+/m0/s1
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InChIKey |
MFQZSFZGLACSHP-LPOYSWGPSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Plasmodium Plasmepsin 2 (Malaria PLA2) | Target Info | Inhibitor | [1] |
References | Top | |||
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REF 1 | Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. |
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