Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E6DI
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| Former ID |
DCL000239
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| Drug Name |
T487
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| Synonyms |
AC1MVK5U; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methyl-ethanamine; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methylethanamine
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| Drug Type |
Small molecular drug
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| Indication | Psoriatic disorder [ICD-11: EA90; ICD-9: 696] | Discontinued in Phase 2 | [1] | |
| Inflammation [ICD-11: 1A00-CA43.1] | Discontinued in Phase 1 | [1] | ||
| Company |
Amgen
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| Structure |
 |
Download2D MOL |
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| Formula |
C12H10N4O2
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| Canonical SMILES |
C1=CC(=CC=C1N)N=NC2=CC=C(C=C2)[N+](=O)[O-]
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| InChI |
1S/C12H10N4O2/c13-9-1-3-10(4-2-9)14-15-11-5-7-12(8-6-11)16(17)18/h1-8H,13H2
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| InChIKey |
UNBOSJFEZZJZLR-UHFFFAOYSA-N
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| CAS Number |
CAS 730-40-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:75648
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-X-C chemokine receptor type 3 (CXCR3) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathway Interaction Database | CXCR3-mediated signaling events | |||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of ChemoCentryx. | |||
| REF 2 | Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. | |||
| REF 3 | FANCG is phosphorylated at serines 383 and 387 during mitosis. Mol Cell Biol. 2004 Oct;24(19):8576-85. | |||
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