Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E4IB
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| Drug Name |
PBF509
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| Synonyms |
5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine; 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine; SCHEMBL2546228; CHEMBL3694769; ATFXVNUWQOXRRU-UHFFFAOYSA-N; BDBM128295; ZINC72317391; AKOS030527812; DS-19509; US8796284, 1; 1337962-47-6
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| Indication | Non-small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162] | Phase 1/2 | [1] | |
| Company |
Novartis OncologyEast Hanover, NJ Palobiofarma Barcelona, Spain
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H8BrN7
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| Canonical SMILES |
C1=CN(N=C1)C2=NC(=NC(=C2Br)N)N3C=CC=N3
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| InChI |
1S/C10H8BrN7/c11-7-8(12)15-10(18-6-2-4-14-18)16-9(7)17-5-1-3-13-17/h1-6H,(H2,12,15,16)
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| InChIKey |
ATFXVNUWQOXRRU-UHFFFAOYSA-N
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| CAS Number |
CAS 1337962-47-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Antagonist | [1] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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