Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E0KQ
|
|||
| Former ID |
DAP001508
|
|||
| Drug Name |
Pyronaridine
|
|||
| Synonyms |
Malaridine; Pyronaridine phosphate salt; Benzonaphthyridine 7351; 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine; 4-((7-Chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one; 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C29H32ClN5O2
|
|||
| Canonical SMILES |
COC1=NC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)NC4=CC(=C(C(=C4)CN5CCCC5)O)CN6CCCC6
|
|||
| InChI |
1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)
|
|||
| InChIKey |
DJUFPMUQJKWIJB-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 74847-35-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
14836281, 37375204, 39472434, 50065153, 57364048, 76896800, 90452320, 93625661, 103210597, 113993147, 117793601, 124952509, 125325465, 131801476, 134338695, 135066549, 135959505, 137006529, 144233411, 163667393, 166240084, 174006948, 175265429, 179148054, 198992732, 223705403, 223718772, 226596943, 227839360, 241134503, 251912260, 251916561, 252633485
|
|||
| ChEBI ID |
CHEBI:135951
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.