Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D6XV
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Former ID |
DIB021035
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Drug Name |
TEI-9647
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Synonyms |
TEI9647
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C27H38O4
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Canonical SMILES |
CC(CC1CC(=C)C(=O)O1)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C
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InChI |
1S/C27H38O4/c1-16(12-22-13-17(2)26(30)31-22)23-9-10-24-19(6-5-11-27(23,24)4)7-8-20-14-21(28)15-25(29)18(20)3/h7-8,16,21-25,28-29H,2-3,5-6,9-15H2,1,4H3/b19-7+,20-8-/t16-,21-,22+,23-,24+,25+,27-/m1/s1
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InChIKey |
SAODSJHDCZTVAT-CZADFQNYSA-N
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CAS Number |
CAS 173388-20-0
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:156177
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Target and Pathway | Top | |||
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Target(s) | Vitamin D3 receptor (VDR) | Target Info | Antagonist | [2] |
KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | |||
Mineral absorption | ||||
Tuberculosis | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
Panther Pathway | Vitamin D metabolism and pathway | |||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Direct p53 effectors | ||||
RXR and RAR heterodimerization with other nuclear receptor | ||||
Retinoic acid receptors-mediated signaling | ||||
Validated transcriptional targets of deltaNp63 isoforms | ||||
Validated transcriptional targets of TAp63 isoforms | ||||
Reactome | Nuclear Receptor transcription pathway | |||
WikiPathways | Ovarian Infertility Genes | |||
Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Nuclear Receptors Meta-Pathway | ||||
Vitamin D Receptor Pathway | ||||
Drug Induction of Bile Acid Pathway | ||||
Nuclear Receptors | ||||
Vitamin D Metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2788). | |||
REF 2 | Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones. J Med Chem. 2006 Nov 30;49(24):7063-75. |
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