Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D1LG
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| Former ID |
DIB000846
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| Drug Name |
AZD-5099
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| Synonyms |
Gyrase B inhibitor (serious infection), AstraZeneca
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| Indication | Infectious disease [ICD-11: 1A00-CA43.1; ICD-9: 001-139] | Discontinued in Phase 1 | [1] | |
| Company |
AstraZeneca plc
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| Structure |
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Download2D MOL |
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| Formula |
C21H27Cl2N5O6S
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| Canonical SMILES |
CC1=C(C(=C(N1)C(=O)NC2CCN(CC2OC)C3=NC(=C(S3)C(=O)O)C(=O)NC(C)COC)Cl)Cl
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| InChI |
1S/C21H27Cl2N5O6S/c1-9(8-33-3)24-19(30)16-17(20(31)32)35-21(27-16)28-6-5-11(12(7-28)34-4)26-18(29)15-14(23)13(22)10(2)25-15/h9,11-12,25H,5-8H2,1-4H3,(H,24,30)(H,26,29)(H,31,32)/t9-,11+,12-/m0/s1
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| InChIKey |
KGZHRAVDXGQUQM-WCQGTBRESA-N
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| CAS Number |
CAS 907543-25-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial DNA gyrase (Bact gyrase) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034406) | |||
| REF 2 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem. 2014 Jul 24;57(14):6060-82. | |||
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