Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D1HR
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| Former ID |
DIB014995
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| Drug Name |
TrkB NAM
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| Synonyms |
TrkB negative allosteric modulators (neurodegenerative diseases); TrkB NAM program (neurodegenerative diseases), Addex; TrkB negative allosteric modulators (neurodegenerative diseases), Addex
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| Indication | Neurodegenerative disorder [ICD-11: 8A20-8A23] | Investigative | [1] | |
| Company |
Addex Pharmaceuticals SA
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | BDNF/NT-3 growth factors receptor (TrkB) | Target Info | Modulator | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| Neurotrophin signaling pathway | ||||
| Alcoholism | ||||
| Pathway Interaction Database | SHP2 signaling | |||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| Neurotrophic factor-mediated Trk receptor signaling | ||||
| Reactome | NGF-independant TRKA activation | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| BDNF signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). | |||
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