Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D1HH
|
|||
| Drug Name |
Carvedilol
|
|||
| Synonyms |
Coreg; Dilatrend; Eucardic; Carvedilolum [Latin]; BM 14190; Carvedilolum; SKF 105517; BM-14190; Coreg CR; DQ 2466; HSDB 7044; DQ-2466
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Congestive heart failure [ICD-11: BD10; ICD-10: I50.0; ICD-9: 428] | Approved | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C24H26N2O4
|
|||
| Canonical SMILES |
COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
|
|||
| InChI |
1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
|
|||
| InChIKey |
OGHNVEJMJSYVRP-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 72956-09-3
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:3441
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUAMN alpha-1 adrenergic receptor (ADRA1) | Target Info | Inhibitor | [3] |
| HUMAN beta adrenergic receptor (BAR) | Target Info | Antagonist | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 078332. | |||
| REF 2 | Can beta-adrenergic blockers be used in the treatment of COVID-19 Med Hypotheses. 2020 May 5;142:109809. | |||
| REF 3 | Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. J Am Coll Cardiol. 2003 Jan 15;41(2):340-5. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.