Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CV7Z
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| Former ID |
DNC000616
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| Drug Name |
Epothilone B
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| Synonyms |
Epothilone B; Patupilone; 152044-54-7; (-)-Epothilone B; Epo B; EpoB; EPO906; EPO 906; UNII-UEC0H0URSE; EPO 906A; GNF-PF-193; CHEBI:31550; UEC0H0URSE; AK163080; Epothilone B (EPO906, Patupilone); 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE; Epothilon B; Patupilone [INN]; (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Discontinued in Phase 3 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C27H41NO6S
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| Canonical SMILES |
CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
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| InChI |
1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
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| InChIKey |
QXRSDHAAWVKZLJ-PVYNADRNSA-N
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| CAS Number |
CAS 152044-54-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14301, 520207, 830084, 7887332, 10300156, 12014962, 14762393, 14860221, 17424973, 24724475, 36553605, 49963244, 50125842, 57404848, 74380521, 80868833, 99437114, 103306054, 104638848, 124772091, 125163996, 126623079, 126671632, 131299984, 131333506, 131480855, 136367402, 136367813, 137262638, 142438244, 152090491, 152258740, 152344296, 160647585, 162011973, 162037563, 162172155, 164841003, 172125880, 177748943, 179117109, 184812277, 198964552, 221678840, 223404331, 223660093, 223702472, 226395914, 243996700, 249719024
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| ChEBI ID |
CHEBI:31550
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005849) | |||
| REF 2 | Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. | |||
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