Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CT7M
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| Former ID |
DIB009653
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| Drug Name |
A-6
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| Synonyms |
Angstrom-6; CD44 binding peptide (cancer), Angstrom
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| Indication | Macular degeneration [ICD-11: 9B78.3; ICD-10: H35.3; ICD-9: 362.5] | Phase 2 | [1] | |
| Company |
Angstrom pharmaceuticals
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Extracellular matrix receptor III (CD44) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | ECM-receptor interaction | |||
| Hematopoietic cell lineage | ||||
| Shigellosis | ||||
| Epstein-Barr virus infection | ||||
| Proteoglycans in cancer | ||||
| MicroRNAs in cancer | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Osteopontin-mediated events | |||
| a4b7 Integrin signaling | ||||
| Reactome | Degradation of the extracellular matrix | |||
| Cell surface interactions at the vascular wall | ||||
| Integrin cell surface interactions | ||||
| Hyaluronan uptake and degradation | ||||
| Interferon gamma signaling | ||||
| WikiPathways | Senescence and Autophagy in Cancer | |||
| Wnt Signaling Pathway and Pluripotency | ||||
| Glycosaminoglycan metabolism | ||||
| Extracellular matrix organization | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011940) | |||
| REF 2 | Modulation of CD44 Activity by A6-Peptide.Front Immunol.2015 Mar 30;6:135. | |||
| REF 3 | A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells.Mol Cancer Ther.2011 Nov;10(11):2072-82. | |||
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