Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C4QN
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| Former ID |
DIB011818
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| Drug Name |
ROTIGAPTIDE
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| Synonyms |
GAP-486; Rotigaptide < USAN; ZP-123; N-Acetyl-D-tyrosyl-D-prolyl-4(S)-hydroxy-D-prolyl-glycyl-D-alanyl-glycinamide
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| Drug Type |
Small molecular drug
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| Indication | Cardiac arrhythmias [ICD-11: BC9Z; ICD-9: 427] | Phase 2 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C28H39N7O9
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| Canonical SMILES |
CC(C(=O)NCC(=O)N)NC(=O)CNC(=O)C1CC(CN1C(=O)C2CCCN2C(=O)C(CC3=CC=C(C=C3)O)NC(=O)C)O
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| InChI |
1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
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| InChIKey |
GFJRASPBQLDRRY-TWTQBQJDSA-N
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| CAS Number |
CAS 355151-12-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gap junction protein (GJP) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00137332) Study Evaluating GAP-486 on Heart Rhythm in Patients With Coronary Artery Disease. U.S. National Institutes of Health. | |||
| REF 2 | The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Br J Pharmacol. 2006 Mar;147(5):486-95. | |||
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