Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0BV3J
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| Former ID |
DIB013193
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| Drug Name |
Macimorelin
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| Synonyms |
Solorel; AEZS-130; ARD-07; ARD-0705; EP-01572; EP-1572; JMV-1843
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| Drug Type |
Small molecular drug
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| Indication | Growth hormone deficiency [ICD-11: 5A61.3] | Approved | [1] | |
| Somatotropin deficiency [ICD-11: 5A61.0] | Approved | [2] | ||
| Company |
Aeterna Zentaris
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H30N6O3
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| Canonical SMILES |
CC(C)(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CNC4=CC=CC=C43)NC=O)N
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| InChI |
1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1
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| InChIKey |
UJVDJAPJQWZRFR-DHIUTWEWSA-N
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| CAS Number |
CAS 381231-18-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Agonist | [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||
| REF 3 | National Cancer Institute Drug Dictionary (drug id 735530). | |||
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