Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0BE9U
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| Drug Name |
Pyrimidinyl pyrazolamine derivative 1
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| Synonyms |
PMID25656651-Compound-14
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| Drug Type |
Small molecular drug
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| Company |
IRM LLC NOVARTIS AG ALBAUGH, Pamela CHOPIUK, Gregory S. DING, Qiang HUANG, Shenlin LIU, Zuosheng PAN, Shifeng REN, Pingda WANG, Xia WANG, Xing XIE, Yongping ZHANG, Chengzhi ZHANG, Qiong ZHANG, Guobao POON, Daniel RENHOWE, Paul SENDZIK, Martin
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| Structure |
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Download2D MOL |
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| Formula |
C28H31F3N8O
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| Canonical SMILES |
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC(=C2)CNC(C)C)C(F)(F)F)NC3=CC(=NN3C4=NC=NC(=C4)NC)C
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| InChI |
1S/C28H31F3N8O/c1-16(2)33-14-19-9-20(11-21(10-19)28(29,30)31)27(40)36-22-7-6-17(3)23(12-22)37-26-8-18(4)38-39(26)25-13-24(32-5)34-15-35-25/h6-13,15-16,33,37H,14H2,1-5H3,(H,36,40)(H,32,34,35)
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| InChIKey |
ZBUIYGDQZSKXHD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fusion protein Bcr-Abl (Bcr-Abl) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Fusion protein Bcr-Abl (Bcr-Abl) | Target's Patent Info | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. | |||
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