Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0B9GM
|
|||
Former ID |
DIB014176
|
|||
Drug Name |
Oxibendazole
|
|||
Synonyms |
Oxibendazole, GlaxoSmithKline
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Pediatric cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-C96; ICD-9: 140-229] | Discontinued in Phase 3 | [1] | |
Company |
GlaxoSmithKline
|
|||
Structure |
Download2D MOL |
|||
Formula |
C12H15N3O3
|
|||
Canonical SMILES |
CCCOC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
|
|||
InChI |
1S/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
|
|||
InChIKey |
RAOCRURYZCVHMG-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 20559-55-1
|
|||
PubChem Compound ID | ||||
ChEBI ID |
CHEBI:92907
|
Interaction between the Drug and Microbe | Top | |||
---|---|---|---|---|
The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
Show/Hide Hierarchy
|
[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Oxibendazol (adjusted p-values: 6.15E-03). |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Polymerase unspecific (POL) | Target Info | Inhibitor | [3] |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018000) | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 3 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.