Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B9EZ
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| Former ID |
DNC004800
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| Drug Name |
2-(piperidin-1-yl)-4H-benzo[h]chromen-4-one
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| Synonyms |
K 12212; BRN 0415699; 4H-Naphtho(1,2-b)pyran-4-one, 2-(1-piperidinyl)-; CHEMBL367468; 2-(1-Piperidinyl)-4H-naphtho(1,2-b)pyran-4-one; 2-(N-Piperidil)-4-oxo-4H-nafto(1,2-b)pirano [Italian]; 61035-05-0; AC1MIJ0F; 2-(piperidin-1-yl)-4H-benzo[h]chromen-4-one; 2-(N-Piperidil)-4-oxo-4H-nafto(1,2-b)pirano; SCHEMBL3538224; DTXSID60209911; BDBM50159645; 2-piperidin-1-ylbenzo[h]chromen-4-one; LS-95581
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C18H17NO2
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| Canonical SMILES |
C1CCN(CC1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
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| InChI |
1S/C18H17NO2/c20-16-12-17(19-10-4-1-5-11-19)21-18-14-7-3-2-6-13(14)8-9-15(16)18/h2-3,6-9,12H,1,4-5,10-11H2
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| InChIKey |
MAIHLQWUOLIOEP-UHFFFAOYSA-N
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| CAS Number |
CAS 61035-05-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. | |||
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