Drug Information
Drug General Information | Top | |||
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Drug ID |
D0B7HJ
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Former ID |
DIB006082
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Drug Name |
U-54494A
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Synonyms |
C18H24Cl2N2O; U 54494A; U 54494; U-54494; U-54494A; cis-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)benzamide; Benzamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, trans-; AC1L3TTM; 92953-41-8; AC1Q3O5Y; SCHEMBL11610023; 3,4-dichloro-n-methyl-n-[(1r,2r)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide; LS-178194; A845921; UNII-I3NE36R0XJ component JUBNVWGVNWIXMB-IAGOWNOFSA-N; trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide
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Drug Type |
Small molecular drug
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Indication | Epilepsy [ICD-11: 8A60-8A68] | Terminated | [1] | |
Company |
Pharmacia & Upjohn Co
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Structure |
Download2D MOL |
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Formula |
C18H24Cl2N2O
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Canonical SMILES |
CN(C1CCCCC1N2CCCC2)C(=O)C3=CC(=C(C=C3)Cl)Cl
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InChI |
1S/C18H24Cl2N2O/c1-21(18(23)13-8-9-14(19)15(20)12-13)16-6-2-3-7-17(16)22-10-4-5-11-22/h8-9,12,16-17H,2-7,10-11H2,1H3/t16-,17-/m1/s1
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InChIKey |
JUBNVWGVNWIXMB-IAGOWNOFSA-N
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CAS Number |
CAS 92953-41-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [2] |
KEGG Pathway | Dopaminergic synapse | |||
Reactome | Interaction between L1 and Ankyrins |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002236) | |||
REF 2 | U-54494A: a unique anticonvulsant related to kappa opioid agonists. J Pharmacol Exp Ther. 1987 Nov;243(2):542-7. |
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