Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B6MQ
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| Former ID |
DIB020744
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| Drug Name |
polyIC
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| Synonyms |
poly(I:C); polyinosine:polycytidylic acid; polyinosine-polycytosine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 3 (TLR3) | Target Info | Agonist | [2] |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Hepatitis C | ||||
| Hepatitis B | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Toll receptor signaling pathway | |||
| Pathway Interaction Database | Endogenous TLR signaling | |||
| Reactome | Ligand-dependent caspase activation | |||
| MyD88-independent TLR3/TLR4 cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| RIP-mediated NFkB activation via ZBP1 | ||||
| TRIF-mediated programmed cell death | ||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
| IKK complex recruitment mediated by RIP1 | ||||
| TRAF6 mediated induction of TAK1 complex | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Toll-Like Receptors Cascades | ||||
| MyD88-independent cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5047). | |||
| REF 2 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8. | |||
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