Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B6DN
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| Drug Name |
Ethinyl-pyrazole derivative 3
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| Synonyms |
PMID25435285-Compound-73
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| Drug Type |
Small molecular drug
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| Company |
TAISHO PHARMACEUTICAL CO., LTD. NAKAMURA Toshio SAKAGAMI Kazunari KONISHI Kazuhide YAMAMOTO Kanako MASUDA Seiji
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| Structure |
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Download2D MOL |
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| Formula |
C20H17ClN4O2S
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| Canonical SMILES |
CN1C(=C(C=N1)C#CC2=CC=C(C=C2)S(=O)(=O)N)N3CC4=C(C3)C=C(C=C4)Cl
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| InChI |
1S/C20H17ClN4O2S/c1-24-20(25-12-16-6-7-18(21)10-17(16)13-25)15(11-23-24)5-2-14-3-8-19(9-4-14)28(22,26)27/h3-4,6-11H,12-13H2,1H3,(H2,22,26,27)
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| InChIKey |
CAOKQZMINRCCBM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
| Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Cocaine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. | |||
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