Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B5MP
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| Former ID |
DAP000816
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| Drug Name |
Aciclovir
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| Synonyms |
acyclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral; Virorax; Wellcome-248U; 9-[(2-Hydroxyethoxy)methyl]guanine; Aciclovirum; Zovir; Aciclovirum [Latin]; Sitavig; Aciclovier; Zyclir; 9-HYROXYETHOXYMETHYLGUANINE; Aciclovirum [INN-Latin]; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; W-248-U; 9-(2-Hydroxyethoxy)methylguanine; Acyclovir-side chain-2-3H; ACYCLOVIR SODIUM; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Cargosil; BW-248U; UNII-X4HES1O11F; DRG-0008; NSC 645011; CHEBI:2453; CCRIS 1953; Iontophoretic acyclovir
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Approved | [1], [2] | |
| Herpes simplex virus infection [ICD-11: 1F00; ICD-10: B00; ICD-9: 54] | Phase 3 | [3] | ||
| Therapeutic Class |
Antiviral Agents
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| Company |
GlaxoSmithKline
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H11N5O3
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| Canonical SMILES |
C1=NC2=C(N1COCCO)N=C(NC2=O)N
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| InChI |
1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
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| InChIKey |
MKUXAQIIEYXACX-UHFFFAOYSA-N
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| CAS Number |
CAS 59277-89-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9029, 502278, 594925, 603044, 794369, 829893, 855732, 1916590, 5344000, 5344001, 6855606, 7847289, 7885662, 7978637, 8150001, 8151390, 10321108, 10589392, 11110742, 11110743, 11335360, 11360599, 11364633, 11367195, 11369757, 11372947, 11374028, 11377919, 11461571, 11466114, 11467234, 11485202, 11485687, 11489379, 11491689, 11492040, 11495553, 11528717, 12013356, 14773677, 15172245, 15220533, 17404601, 24278078, 24890562, 25621755, 26612492, 26679648, 26747423, 26747424
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| ChEBI ID |
CHEBI:2453
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| ADReCS Drug ID | BADD_D00039 ; BADD_D00040 | |||
| SuperDrug ATC ID |
D06BB03; J05AB01; S01AD03
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| SuperDrug CAS ID |
cas=059277893
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Modulator | [4] |
| Varicella-zoster virus DNA polymerase (VZV ORF28) | Target Info | Modulator | [5] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4829). | |||
| REF 2 | Drug information of Aciclovir, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
| REF 5 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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