Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B4FN
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| Former ID |
DNC006228
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| Drug Name |
2pyrrolidin-1-yl-1-phenylpentan-1-one
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| Synonyms |
14530-33-7; alpha-PVP; 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one; alpha-pyrrolidinovalerophenone; Desmethyl pyrovalerone; Alpha-Pyrrolidinopentiophenone; CHEMBL205082; 1-Pentanone, 1-phenyl-2-(1-pyrrolidinyl)-; Flakka; beta-Ketone-prolintane; Prolintanone; Gravel; beta-Keto-prolintane; a-PVP; 2pyrrolidin-1-yl-1-phenylpentan-1-one; 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone; a-Pyrrolidinopentiophenone; O-2387; SCHEMBL4936204; DTXSID70456954; YDIIDRWHPFMLGR-UHFFFAOYSA-N; MFCD24386810; BDBM50182584; alpha-Pyrrolidinopentiophenone, a-PVP
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H21NO
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| Canonical SMILES |
CCCC(C(=O)C1=CC=CC=C1)N2CCCC2
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| InChI |
1S/C15H21NO/c1-2-8-14(16-11-6-7-12-16)15(17)13-9-4-3-5-10-13/h3-5,9-10,14H,2,6-8,11-12H2,1H3
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| InChIKey |
YDIIDRWHPFMLGR-UHFFFAOYSA-N
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| CAS Number |
CAS 14530-33-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [1] |
| Norepinephrine transporter (NET) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. | |||
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