Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0AK9X
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| Former ID |
DNC014693
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| Drug Name |
4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid
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| Synonyms |
133933-81-0; 4-amino-3-(5-chlorothiophen-2-yl)butanoic acid; CHEMBL87482; 4-AMINO-3- (5-CHLOROTHIEN-2-YL)BUTANOIC ACID; 2-Thiophenepropanoicacid, b-(aminomethyl)-5-chloro-; (+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID; 4-Actba; KBio3_002901; ACMC-20mv5p; AC1L2PFH; Spectrum2_001171; Spectrum3_001889; Spectrum4_000231; Spectrum5_001875; 4-Amino-3-(5-chloro-2-thienyl)butyric acid; Biomol-NT_000250; BSPBio_003398; KBioGR_000921; 4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid; SCHEMBL342009; SPBio_001181; BPBio1_000706
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H10ClNO2S
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| Canonical SMILES |
C1=C(SC(=C1)Cl)C(CC(=O)O)CN
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| InChI |
1S/C8H10ClNO2S/c9-7-2-1-6(13-7)5(4-10)3-8(11)12/h1-2,5H,3-4,10H2,(H,11,12)
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| InChIKey |
CDFQDLUHBLZCGL-UHFFFAOYSA-N
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| CAS Number |
CAS 151563-54-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. | |||
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