Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AD4H
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| Former ID |
DCL000747
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| Drug Name |
Cethrin
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| Synonyms |
Quinacrine, Dihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Spinal cord injury [ICD-11: ND51.2] | Phase 1/2 | [1] | |
| Company |
Alseres Pharmaceuticals Purchased rights for Cethrin from BioAxone Therapeutic
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H32Cl3N3O
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| Canonical SMILES |
CCN(CC)CCCC(C)NC1=CC(=CC2=C1C=C3C=C(C=CC3=N2)OC)Cl.Cl.Cl
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| InChI |
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)11-7-8-16(3)25-22-14-18(24)15-23-20(22)13-17-12-19(28-4)9-10-21(17)26-23;;/h9-10,12-16,25H,5-8,11H2,1-4H3;2*1H
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| InChIKey |
QKAZHUGLNKCCGY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
P01AX05
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| SuperDrug CAS ID |
cas=000083896
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Rho-associated protein kinase (ROCK) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80. | |||
| REF 2 | A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011 May;28(5):787-96. | |||
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