Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A9JW
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| Former ID |
DIB011905
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| Drug Name |
GPG
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| Synonyms |
AlfaHGA
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Discontinued in Phase 1/2 | [1] | |
| Company |
Tripep
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| Structure |
 |
Download2D MOL
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| Formula |
C22H29N10O10P
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| Canonical SMILES |
C1C(C(C(C1N2C=NC3=C2N=C(NC3=O)N)O)OP(=O)(O)OCC4CC(C(C4O)O)N5C=NC6=C5N=C(NC6=O)N)CO
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| InChI |
1S/C22H29N10O10P/c23-21-27-17-11(19(37)29-21)25-5-31(17)9-2-8(13(34)14(9)35)4-41-43(39,40)42-16-7(3-33)1-10(15(16)36)32-6-26-12-18(32)28-22(24)30-20(12)38/h5-10,13-16,33-36H,1-4H2,(H,39,40)(H3,23,27,29,37)(H3,24,28,30,38)/t7-,8-,9-,10-,13-,14+,15+,16-/m1/s1
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| InChIKey |
WGYAYVXBDYHRBW-QPVXRGBGSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:165826
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021646) | |||
| REF 2 | GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway. Retrovirology 2010, 7:20. | |||
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