Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A8XN
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| Former ID |
DAP000038
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| Drug Name |
Labetalol
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| Synonyms |
Albetol; Ibidomide; Labetalolum; Labetolol; NORMOZIDE; AH 5158; AH-5158; Labetalol (INN); Labetalol [INN:BAN]; Labetalolum [INN-Latin]; Normodyne (TN); Sch-19927; Trandate (TN); 2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzamide; 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide; 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol; 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Allen & Handbury
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H24N2O3
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| Canonical SMILES |
CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O
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| InChI |
1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
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| InChIKey |
SGUAFYQXFOLMHL-UHFFFAOYSA-N
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| CAS Number |
CAS 36894-69-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9275, 5142009, 7979714, 8152441, 11335649, 11360888, 11364501, 11367063, 11369625, 11372741, 11373866, 11377787, 11461860, 11466305, 11467425, 11484641, 11486109, 11488679, 11491396, 11491999, 11495421, 14777379, 29222985, 46505511, 47216734, 47736423, 47885363, 48184950, 48259181, 48259182, 48259183, 48259184, 48416150, 49698939, 49832659, 49876891, 50105268, 53790399, 56413046, 56464163, 57322029, 77168696, 85209992, 85788805, 90341718, 92716935, 96024796, 103165317, 104304757, 118314781
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| ChEBI ID |
CHEBI:6343
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| ADReCS Drug ID | BADD_D01236 ; BADD_D01237 | |||
| SuperDrug ATC ID |
C07AG01
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| SuperDrug CAS ID |
cas=036894696
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-1 (ADRA1) | Target Info | Antagonist | [3] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7207). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074787. | |||
| REF 3 | Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. | |||
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