Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A3RP
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Drug Name |
Fedratinib
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Synonyms |
Tg-101348; TG101348; TG 101348; SAR302503; UNII-6L1XP550I6; SAR-302503; Fedratinib (SAR302503, TG101348); TG101348 (SAR302503); SAR 302503; CHEMBL1287853; C27H36N6O3S; 6L1XP550I6
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Drug Type |
Small molecular drug
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Indication | Polycythemia vera [ICD-11: 2A20.4; ICD-10: D45] | Approved | [1] | |
Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
Therapeutic Class |
Antiviral Agents
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Structure |
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Download2D MOL |
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Formula |
C27H36N6O3S
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Canonical SMILES |
CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
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InChI |
1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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InChIKey |
JOOXLOJCABQBSG-UHFFFAOYSA-N
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CAS Number |
CAS 936091-26-8
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:91408
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Target and Pathway | Top | |||
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Target(s) | HUMAN janus kinase 2 (JAK-2) | Target Info | Inhibitor | [2] |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (NDA) 212327 | |||
REF 2 | TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J Microbiol Immunol Infect. 2020 Mar 11. pii: S1684-1182(20)30065-7. |
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