Drug Information
Drug General Information | Top | |||
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Drug ID |
D09YOU
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Drug Name |
MK-0343
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Synonyms |
GABA-A alpha-2/alpha-3 agonists (anxiolytics), Merck & Co; IDDBCP174406; MRK-409; TPA-023B
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H17F2N7O
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Canonical SMILES |
CN1C(=NC=N1)COC2=NN3C(=NN=C3C4=C(C=CC=C4F)F)C=C2C5CCC5
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InChI |
1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3
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InChIKey |
GOIFCXRIFSYPFG-UHFFFAOYSA-N
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CAS Number |
CAS 233275-76-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Modulator | [1] |
GABA(A) receptor alpha-3 (GABRA3) | Target Info | Modulator | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
Iron uptake and transport |
References | Top | |||
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REF 1 | Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers.J Psychopharmacol.2008 Jan;22(1):24-32. |
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