Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09WFI
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| Former ID |
DIB012809
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| Drug Name |
Tetramethylpyrazine
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| Synonyms |
Ligustizine; Ligustrazine; 2,3,5,6-Tetramethylpyrazine
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| Drug Type |
Small molecular drug
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| Indication | Neurological disorder [ICD-11: 6B60] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H12N2
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| Canonical SMILES |
CC1=C(N=C(C(=N1)C)C)C
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| InChI |
1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
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| InChIKey |
FINHMKGKINIASC-UHFFFAOYSA-N
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| CAS Number |
CAS 1124-11-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:133246
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endothelin-1 (EDN1) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Determination of tetramethylpyrazine in animal serum and cerebrospinal fluid by high performance liquid chromatography. Se Pu. 2000 Jan;18(1):46-8. | |||
| REF 2 | Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S313-6. | |||
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