Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09TGC
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| Former ID |
DIB005273
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| Drug Name |
MK-1903
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| Synonyms |
Second-generation niacin receptor agonists (oral, atherosclerosis), Arena/Merck & Co
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD-11: BD40; ICD-9: 440] | Phase 2 | [1], [2] | |
| Company |
Arena Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H8N2O2
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| Canonical SMILES |
C1C2C1C3=C(C2)C(=NN3)C(=O)O
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| InChI |
1S/C8H8N2O2/c11-8(12)7-5-2-3-1-4(3)6(5)9-10-7/h3-4H,1-2H2,(H,9,10)(H,11,12)/t3-,4-/m1/s1
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| InChIKey |
CUTZNERBKDMLAP-QWWZWVQMSA-N
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| CAS Number |
CAS 1268882-43-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acid receptor (HCAR2) | Target Info | Agonist | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5785). | |||
| REF 2 | ClinicalTrials.gov (NCT00847197) A Study to Evaluate MK1903 in Patients With Dyslipidemia (MK1903-004). U.S. National Institutes of Health. | |||
| REF 3 | Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med. 2012 Aug 22;4(148):148ra115. | |||
| REF 4 | Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. | |||
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