Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09SXN
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| Former ID |
DIB020307
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| Drug Name |
MAP4
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| Synonyms |
MAP4; (S)-2-Amino-2-methyl-4-phosphonobutanoic acid; 157381-42-5; (2S)-2-amino-2-methyl-4-phosphonobutanoic acid; Tocris-0711; AC1LX6MM; MAP-4; SCHEMBL179781; GTPL1414; CHEMBL1488784; MolPort-003-983-618; ZINC2139819; BN0320; AKOS006272533; NCGC00024744-02; NCGC00024744-01; B6414; SR-01000597625; 381A425; J-009412
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C5H12NO5P
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| Canonical SMILES |
CC(CCP(=O)(O)O)(C(=O)O)N
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| InChI |
1S/C5H12NO5P/c1-5(6,4(7)8)2-3-12(9,10)11/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11)/t5-/m0/s1
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| InChIKey |
HONKEGXLWUDTCF-YFKPBYRVSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 4 (mGluR4) | Target Info | Antagonist | [2] |
| Metabotropic glutamate receptor 6 (mGluR6) | Target Info | Antagonist | [3] | |
| Metabotropic glutamate receptor 7 (mGluR7) | Target Info | Antagonist | [4] | |
| Metabotropic glutamate receptor 8 (mGluR8) | Target Info | Antagonist | [5] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Taste transduction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1414). | |||
| REF 2 | Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. | |||
| REF 3 | The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317. | |||
| REF 4 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | |||
| REF 5 | Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90. | |||
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