Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09REZ
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| Drug Name |
PMID27724045-Compound-14
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| Drug Type |
Small molecular drug
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| Company |
Janssen Pharmaceutica
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H15ClF4N6O
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| Canonical SMILES |
C1CC2CN3C(=NN=C3C4=NC=C(C=N4)F)C(C1)N2C(=O)C5=C(C(=CC=C5)C(F)(F)F)Cl
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| InChI |
1S/C20H15ClF4N6O/c21-15-12(4-2-5-13(15)20(23,24)25)19(32)31-11-3-1-6-14(31)17-28-29-18(30(17)9-11)16-26-7-10(22)8-27-16/h2,4-5,7-8,11,14H,1,3,6,9H2/t11-,14+/m1/s1
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| InChIKey |
OKEUHBTYCIUVSL-RISCZKNCSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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