Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09KKU
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| Former ID |
DNC000868
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| Drug Name |
Lefaxin
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| Synonyms |
PYRIDOSTIGMINE BROMIDE; 101-26-8; Mestinon; Kalimin; Regonal; Kalymin; Mestinon bromide; 3-((Dimethylcarbamoyl)oxy)-1-methylpyridin-1-ium bromide; 3-(Dimethylcarbamoyloxy)-1-methylpyridinium Bromide; Pyridostigmine (bromide); UNII-KVI301NA53; Piridostigmina bromuro [DCIT]; CCRIS 6798; HSDB 3924; 3-[(dimethylcarbamoyl)oxy]-1-methylpyridin-1-ium bromide; Pyridostigmini bromidum [INN-Latin]; EINECS 202-929-9; Ro 1-5130; Bromure de pyridostigmine [INN-French]; Pyridostigmini bromidum; Bromuro de piridostigmina [INN-Spanish
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H13BrN2O2
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| Canonical SMILES |
C[N+]1=CC=CC(=C1)OC(=O)N(C)C.[Br-]
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| InChI |
1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
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| InChIKey |
VNYBTNPBYXSMOO-UHFFFAOYSA-M
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| CAS Number |
CAS 101-26-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
518187, 855974, 7847553, 8149951, 8155122, 15197064, 17405593, 24277865, 26612441, 26679847, 26747656, 26747657, 29226381, 48416499, 48424020, 49854543, 50106936, 50106937, 53778141, 53790209, 56422100, 57324314, 78628951, 85089050, 85174466, 87575426, 91011577, 92124809, 92303343, 92307824, 99301295, 103213502, 104170079, 104253248, 104315283, 117370119, 118047400, 118816708, 121362055, 121362581, 124638120, 124757370, 124800762, 125164174, 125336570, 126617391, 126659958, 126664369, 134340174, 134340399
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| ChEBI ID |
CHEBI:8666
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| ADReCS Drug ID | BADD_D01882 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Coagulation factor Xa (F10) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
| Intrinsic Pathway of Fibrin Clot Formation | ||||
| Common Pathway of Fibrin Clot Formation | ||||
| Gamma-carboxylation of protein precursors | ||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. | |||
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