Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09IJN
|
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| Former ID |
DNC010237
|
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| Drug Name |
NSC-745886
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C17H14N2O2
|
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| Canonical SMILES |
CC1(N=C2C=CC3=C(C4=CC=CC=C4C(=C3C2=N1)O)O)C
|
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| InChI |
1S/C17H14N2O2/c1-17(2)18-12-8-7-11-13(14(12)19-17)16(21)10-6-4-3-5-9(10)15(11)20/h3-8,20-21H,1-2H3
|
|||
| InChIKey |
HQLMOIOGHONOJD-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
| KEGG Pathway | HTLV-I infection | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| Regulation of Telomerase | ||||
| IL2 signaling events mediated by PI3K | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
| WikiPathways | TGF beta Signaling Pathway | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Telomere Maintenance | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. | |||
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