Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09IGN
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| Drug Name |
Pyrrolidine derivative 8
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| Synonyms |
PMID25828189-Compound-27
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| Drug Type |
Small molecular drug
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| Company |
SCHERING CORPORATION GILBERT, Eric, J. MILLER, Michael, W. DEMONG, Duane Eugene STAMFORD, Andrew, W. GREENLEE, William, J
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| Structure |
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Download2D MOL |
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| Formula |
C31H28Cl2N2O6S
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| Canonical SMILES |
COC1=CC2=C(C=C1)C=C(C=C2)C3CC(CN3S(=O)(=O)C4=CC=C(C=C4)C(=O)NCCC(=O)O)C5=CC(=CC(=C5)Cl)Cl
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| InChI |
1S/C31H28Cl2N2O6S/c1-41-27-7-4-20-12-22(3-2-21(20)15-27)29-16-24(23-13-25(32)17-26(33)14-23)18-35(29)42(39,40)28-8-5-19(6-9-28)31(38)34-11-10-30(36)37/h2-9,12-15,17,24,29H,10-11,16,18H2,1H3,(H,34,38)(H,36,37)/t24-,29-/m1/s1
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| InChIKey |
DOKNZWNPLZNQJB-FUFSCUOVSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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