Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09EBS
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| Former ID |
DAP000235
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| Drug Name |
Oxymetazoline
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| Synonyms |
Hazol; Iliadin; Nafrine; Navasin; Navisin; Nezeril; Oximetazolina; Oximetazolinum; Oxylazine; Oxymetazolinum; Oxymethazoline; Oxymetozoline; Rhinofrenol; Rhinolitan; Sinerol; Dristan Long Lasting Mentholated Nasal Spray; Dristan Long Lasting Nasal Mist; Drixoral Nasal Solution; Oxymeta zoline; Oxymetazoline hydrochloride crystalline; Afrin Cherry 12 Hour Nasal Spray; Afrin Extra Moisturizing 12 Hour Nasal Spray; Afrin Original 12 Hour Nasal Spray; Afrin Original 12 Hour Nose Drops; Afrin Original 12 Hour Pump Mist; Afrin Sinus 12 Hour Nasal Spray; Duramist Plus Up To 12 Hour Nasal Decongestant Spray; Genasal Nasal Spray Up to 12 Hour Relief; H 990; Nasal Relief 12 Hour Nasal Spray; Nostrilla 12 Hour Nasal Decongestant; Vicks Sinex 12 Hour Nasal Spray; Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief; Decongestant (TN); Neo-Synephrine 12 Hour Spray; Operil (TN); Oximetazolina [INN-Spanish]; Oxymetazoline (INN); Oxymetazoline [INN:BAN]; Oxymetazolinum [INN-Latin]; Visine L.R; Visine L.R.; Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-(7CI,8CI); Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-(9CI); 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline; 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butyl-phenol; 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol; 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
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| Drug Type |
Small molecular drug
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| Indication | Eye inflammation [ICD-11: 9A02] | Approved | [1] | |
| Nasal congestion [ICD-11: MD11.9] | Approved | [1] | ||
| Therapeutic Class |
Nasal Decongestants
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| Company |
Schein Pharmaceutical
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H24N2O
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| Canonical SMILES |
CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C
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| InChI |
1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
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| InChIKey |
WYWIFABBXFUGLM-UHFFFAOYSA-N
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| CAS Number |
CAS 1491-59-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9567, 840961, 841971, 5214260, 7980233, 8152848, 10508603, 11111570, 11111571, 11113337, 11335742, 11360981, 11363945, 11366507, 11369069, 11371745, 11374047, 11377231, 11461953, 11466252, 11467372, 11484831, 11485924, 11488814, 11490349, 11492279, 11494865, 15221519, 26751491, 26751492, 29223725, 46505622, 47216754, 47365161, 47365162, 47440226, 47588971, 47810731, 47810732, 47959714, 47959715, 48110433, 49698392, 50005142, 50100299, 50104031, 50611492, 56313774, 57322367, 85209219
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| ChEBI ID |
CHEBI:7862
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| SuperDrug ATC ID |
R01AA05; R01AB07; S01GA04
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| SuperDrug CAS ID |
cas=001491594
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55. | |||
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