Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09BVL
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| Former ID |
DIB002312
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| Drug Name |
NS-1619
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| Synonyms |
NS-1619; 153587-01-0; NS 1619; 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one; NS1619; CHEMBL384903; 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one; CHEBI:34879; 1-(2'-Hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone; 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2h-benzimidazol-2-one; 3-[2-hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Terminated | [1], [2] | |
| Company |
NeuroSearch A/S
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| Structure |
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Download2D MOL |
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| Formula |
C15H8F6N2O2
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| Canonical SMILES |
C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O
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| InChI |
1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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| InChIKey |
YLFMCMWKHSDUCT-UHFFFAOYSA-N
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| CAS Number |
CAS 153587-01-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
854078, 6577391, 8152805, 11111514, 11121490, 11121970, 11362559, 11365121, 11367683, 11370389, 11370390, 11373284, 11375845, 14754822, 17405451, 24277860, 26753617, 26753618, 29223642, 47291252, 47662441, 47662442, 48110587, 50106740, 50106741, 53777998, 56463290, 57322328, 75846816, 85231147, 85788241, 90340582, 91721709, 92304132, 92309841, 99300755, 99302273, 103095961, 103149312, 103508281, 103858528, 104306733, 117504408, 121361510, 124750079, 124800389, 124880834, 124880835, 124880836, 124880837
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| ChEBI ID |
CHEBI:34879
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Charybdotoxin receptor beta-4 (BKbeta4) | Target Info | Modulator | [3] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Vascular smooth muscle contraction | ||||
| Insulin secretion | ||||
| Salivary secretion | ||||
| Pancreatic secretion | ||||
| Reactome | cGMP effects | |||
| WikiPathways | Potassium Channels | |||
| Platelet homeostasis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4272). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001878) | |||
| REF 3 | BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery | |||
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