Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08YHA
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| Former ID |
DNC008338
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| Drug Name |
2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
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| Synonyms |
Xyloidone; Dehydro-alpha-lapachone; 15297-92-4; Dehydrolapachone; DEHYDROPLAPACHONE; Dehydro-.alpha.-lapachol; Dehydro-.alpha.-lapacone; NSC106453; NSC629748; 2,2-Dimethyl-2H-benzo[g]chromene-5,10-dione; Dehydro-.alpha.-lapachone; NSC 629748; NSC 106453; UNII-305WY61CUF; .alpha.-Lapachone, dehydro-; 2H-Naphtho[2,3-b]pyran-5,10-dione, 2,2-dimethyl-; 305WY61CUF; 2,2-dimethylbenzo[g]chromene-5,10-dione; 2H-Naphtho[2,3-b]pyran-5,10-dione,2,2-dimethyl-; 2,2-dimethyl-2H,5H,10H-benzo[g]chromene-5,10-dione; Xyloidone (VAN)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H12O3
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| Canonical SMILES |
CC1(C=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O)C
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| InChI |
1S/C15H12O3/c1-15(2)8-7-11-12(16)9-5-3-4-6-10(9)13(17)14(11)18-15/h3-8H,1-2H3
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| InChIKey |
OWFHAMHRUCUSRM-UHFFFAOYSA-N
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| CAS Number |
CAS 15297-92-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. | |||
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