Drug Information
Drug General Information | Top | |||
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Drug ID |
D08WBJ
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Former ID |
DCL000144
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Drug Name |
KOS-2187
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Drug Type |
Small molecular drug
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Indication | Gastroesophageal reflux disease [ICD-11: DA22.Z] | Phase 1 | [1] | |
Gastrointestinal disease [ICD-11: DE2Z] | Phase 1 | [1] | ||
Company |
Kosan Biosci.
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Structure |
Download2D MOL |
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Formula |
C43H73NO13
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Canonical SMILES |
CC1CC(C(C(O1)OC2C(C(C(C(=O)OC(C(C(C(C(C(CC2(C)O)C)O)C)O)(C)O)C3=CC=CC=C3)C)OC4CC(C(C(O4)C)O)(C)OC)C)O)N(C)C(C)C
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InChI |
1S/C43H73NO13/c1-22(2)44(12)30-19-24(4)53-40(33(30)46)57-37-26(6)34(55-31-21-42(10,52-13)36(48)28(8)54-31)27(7)39(49)56-38(29-17-15-14-16-18-29)43(11,51)35(47)25(5)32(45)23(3)20-41(37,9)50/h14-18,22-28,30-38,40,45-48,50-51H,19-21H2,1-13H3/t23-,24?,25+,26+,27-,28?,30?,31?,32+,33?,34+,35-,36?,37-,38-,40?,41-,42?,43+/m1/s1
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InChIKey |
BCKWPVFDVOGCTM-AFGVNUEFSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Motilin receptor (MLNR) | Target Info | Agonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26. | |||
REF 2 | Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006. |
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