Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08URY
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| Former ID |
DIB018823
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| Drug Name |
alpha-methylphenylalanine
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| Synonyms |
alpha-Methyl-DL-phenylalanine; 1132-26-9; 2-amino-2-methyl-3-phenylpropanoic acid; 2-Amino-2-methyl-3-phenylpropionic acid; alpha-Methylphenylalanine; H--Me-DL-Phe-OH; HYOWVAAEQCNGLE-UHFFFAOYSA-N; alpha-Methyl-DL-phenylalanine, 98%; MFCD00010512; Phenylalanine, alpha-methyl-; 2-amino-2-methyl-3-phenyl-propanoic acid; 2-Methylphenylalanine #; D,L-Phe(alphaMe)-OH; a-methyl-dl-phenylalanine; alpha-me-dl-phenylalanine; Methylphenylalanine, alpha; H-DL-(ME)PHE-OH; dl-alpha-methylphenylalanine; ACMC-1AH59
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C10H13NO2
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| Canonical SMILES |
CC(CC1=CC=CC=C1)(C(=O)O)N
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| InChI |
1S/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)
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| InChIKey |
HYOWVAAEQCNGLE-UHFFFAOYSA-N
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| CAS Number |
CAS 1132-26-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
76244, 6532505, 10234575, 24857247, 44436958, 50075527, 57338412, 76679717, 85087781, 88836008, 104243030, 104380387, 117395765, 125534589, 125534658, 125539584, 126593897, 126690870, 128131845, 131301962, 135065512, 135565947, 142498158, 151981236, 162091526, 162264941, 162289938, 163100990, 164817180, 170505226, 172829552, 178101786, 184563370, 184825840, 202556920, 206257768, 223655303, 223661708, 224088644, 226493621, 242077842, 242078110, 249951750, 251895105, 252309668, 252374878, 252408885
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phenylalanine hydroxylase (PAH) | Target Info | Inhibitor | [2] |
| BioCyc | Phenylalanine degradation/tyrosine biosynthesis | |||
| KEGG Pathway | Phenylalanine metabolism | |||
| Phenylalanine, tyrosine and tryptophan biosynthesis | ||||
| Metabolic pathways | ||||
| Biosynthesis of amino acids | ||||
| Pathwhiz Pathway | Phenylalanine and Tyrosine Metabolism | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Metabolism of amino acids and derivatives | ||||
| Abnormal metabolism in phenylketonuria | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5093). | |||
| REF 2 | Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats. Science. 1976 Jun 4;192(4243):1007-8. | |||
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