Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08UNC
|
|||
| Drug Name |
GPC3 targeting CAR-T cells
|
|||
| Drug Type |
CAR T Cell Therapy
|
|||
| Indication | Hepatocellular carcinoma [ICD-11: 2C12.02; ICD-10: C22.0; ICD-9: 155] | Phase 1 | [1] | |
| Lung squamous cell carcinoma [ICD-11: 2C25.2] | Phase 1 | [1] | ||
| Company |
Second Affiliated Hospital of Guangzhou Medical University
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glypican-3 (GPC3) | Target Info | CAR-T-Cell-Therapy | [1] |
| KEGG Pathway | Proteoglycans in cancer | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Glypican pathway | |||
| Glypican 3 network | ||||
| Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | |||
| HS-GAG degradation | ||||
| Retinoid metabolism and transport | ||||
| WikiPathways | Visual phototransduction | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03198546) GPC3-T2-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression | |||
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