Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08UHV
|
|||
| Former ID |
DNCL002365
|
|||
| Drug Name |
AMG 780
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiopoietin-1 (ANGPT1) | Target Info | Modulator | [2] |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| HIF-1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| FSH Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling | |||
| SHP2 signaling | ||||
| Reactome | Tie2 Signaling | |||
| RAF/MAP kinase cascade | ||||
| WikiPathways | Cell surface interactions at the vascular wall | |||
| Angiogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). Cancer Research. 10/2014; 74(19 Supplement):1022-1022. | |||
| REF 2 | Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). Cancer Research. 10/2014; 74(19 Supplement):1022-1022. | |||
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