Drug Information
Drug General Information | Top | |||
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Drug ID |
D08TQP
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Former ID |
DIB011725
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Drug Name |
INX-189
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Synonyms |
INX-08032; INX-08189; INX-108; Nucleoside polymerase inhibitors (HCV infection), Cardiff University/Rega Institute; Nucleoside polymerase inhibitors (oral, HCV infection), Inhibitex
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Drug Type |
Small molecular drug
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Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Phase 2 | [1] | |
Company |
Cardiff University
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Structure |
Download2D MOL |
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Formula |
C30H39N6O9P
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Canonical SMILES |
CC(C(=O)OCC(C)(C)C)NP(=O)(OCC1C(C(C(O1)N2C=NC3=C2N=C(N=C3OC)N)(C)O)O)OC4=CC=CC5=CC=CC=C54
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InChI |
1S/C30H39N6O9P/c1-17(26(38)42-15-29(2,3)4)35-46(40,45-20-13-9-11-18-10-7-8-12-19(18)20)43-14-21-23(37)30(5,39)27(44-21)36-16-32-22-24(36)33-28(31)34-25(22)41-6/h7-13,16-17,21,23,27,37,39H,14-15H2,1-6H3,(H,35,40)(H2,31,33,34)/t17-,21+,23+,27+,30+,46?/m0/s1
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InChIKey |
YFXGICNMLCGLHJ-RSKRLRQZSA-N
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CAS Number |
CAS 1234490-83-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Inhibitor | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01425970) Chronically-infected HCV Genotype 2 and 3 Treatment-naive Subjects: Part A: Safety and Efficacy of INX-08189 With Peg IFN Alfa-2a and Ribavirin. Part B: INX-08189 in Interferon Free Treatment With Daclatasvir and/or Ribavirin. U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of Bristol-Myers Squibb. |
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