Drug Information
Drug General Information | Top | |||
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Drug ID |
D08SEK
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Former ID |
DIB019829
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Drug Name |
ET bromodomain inhibitor
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Synonyms |
Methyl (2r)-2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]butanoate; ET bromodomain inhibitor; GTPL7808; SCHEMBL16771873
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C23H23ClN4O3
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Canonical SMILES |
CCC(C1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C)C(=O)OC
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InChI |
1S/C23H23ClN4O3/c1-5-17(23(29)31-4)21-22-27-26-13(2)28(22)19-11-10-16(30-3)12-18(19)20(25-21)14-6-8-15(24)9-7-14/h6-12,17,21H,5H2,1-4H3/t17-,21+/m1/s1
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InChIKey |
WGMDCNPABCIZCD-UTKZUKDTSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Bromodomain-containing protein 2 (BRD2) | Target Info | Inhibitor | [1] |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
Pathway Interaction Database | Regulation of retinoblastoma protein | |||
WikiPathways | Chemical Compounds to monitor Proteins |
References | Top | |||
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REF 1 | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 2014 Oct 31;346(6209):638-41. |
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