Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08PNQ
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| Former ID |
DIB003331
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| Drug Name |
Trombodipine
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| Synonyms |
Thrombodipine; PCA-4230
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| Drug Type |
Small molecular drug
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| Indication | Platelet aggregation disorder [ICD-11: 3B62] | Discontinued in Phase 2 | [1] | |
| Company |
Alter SA
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| Structure |
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Download2D MOL |
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| Formula |
C21H24N2O7S
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| Canonical SMILES |
CCOC(=O)C1=C(NC(=C(C1C)C(=O)OCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C)C
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| InChI |
1S/C21H24N2O7S/c1-5-29-20(25)17-12(2)18(14(4)22-13(17)3)21(26)30-11-10-23-19(24)15-8-6-7-9-16(15)31(23,27)28/h6-9,12,22H,5,10-11H2,1-4H3
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| InChIKey |
MCNAAGLIGWJLQX-UHFFFAOYSA-N
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| CAS Number |
CAS 113658-85-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclin D1/E2F pathway (CCND1/E2F pathway) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000277) | |||
| REF 2 | Inhibition of the cyclin D1/E2F pathway by PCA-4230, a potent repressor of cellular proliferation. Br J Pharmacol. 2001 April; 132(7): 1597-1605. | |||
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