Drug Information
Drug General Information | Top | |||
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Drug ID |
D08PMW
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Former ID |
DIB009901
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Drug Name |
BMS-223131
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Synonyms |
4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one
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Indication | Erectile dysfunction [ICD-11: HA01.1; ICD-10: N48.4; ICD-9: 302.72, 607.84] | Phase 2 | [1] | |
Structure |
Download2D MOL |
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Formula |
C18H13ClF3NO3
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Canonical SMILES |
C1=CC2=C(C=C1C(F)(F)F)C(=C(C(=O)N2)CCO)C3=C(C=CC(=C3)Cl)O
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InChI |
1S/C18H13ClF3NO3/c19-10-2-4-15(25)13(8-10)16-11(5-6-24)17(26)23-14-3-1-9(7-12(14)16)18(20,21)22/h1-4,7-8,24-25H,5-6H2,(H,23,26)
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InChIKey |
QESHSZWKJULSAR-UHFFFAOYSA-N
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CAS Number |
CAS 275375-69-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Charybdotoxin receptor beta-4 (BKbeta4) | Target Info | Modulator | [1] |
KEGG Pathway | cGMP-PKG signaling pathway | |||
Vascular smooth muscle contraction | ||||
Insulin secretion | ||||
Salivary secretion | ||||
Pancreatic secretion | ||||
Reactome | cGMP effects | |||
WikiPathways | Potassium Channels | |||
Platelet homeostasis |
References | Top | |||
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REF 1 | Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance ... J Pharmacol Exp Ther. 2005 May;313(2):840-7. |
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