Drug Information
Drug General Information | Top | |||
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Drug ID |
D08PKR
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Former ID |
DNC004476
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Drug Name |
6-Imidazol-1-yl-isoquinoline
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Synonyms |
6-(1H-imidazol-1-yl)isoquinoline
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H9N3
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Canonical SMILES |
C1=CC2=C(C=CN=C2)C=C1N3C=CN=C3
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InChI |
1S/C12H9N3/c1-2-12(15-6-5-14-9-15)7-10-3-4-13-8-11(1)10/h1-9H
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InChIKey |
YACWDKFXWATANA-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aromatase (CYP19A1) | Target Info | Inhibitor | [2] |
Thromboxane-A synthase (TBXAS1) | Target Info | Inhibitor | [1] | |
BioCyc | Superpathway of steroid hormone biosynthesis | |||
Estradiol biosynthesis II | ||||
Estradiol biosynthesis I | ||||
C20 prostanoid biosynthesis | ||||
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolic pathways | ||||
Ovarian steroidogenesis | ||||
Arachidonic acid metabolism | ||||
Platelet activation | ||||
NetPath Pathway | FSH Signaling Pathway | |||
Panther Pathway | Androgen/estrogene/progesterone biosynthesis | |||
Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
Arachidonic Acid Metabolism | ||||
Reactome | Endogenous sterols | |||
WikiPathways | Metapathway biotransformation | |||
Tryptophan metabolism | ||||
Oxidation by Cytochrome P450 | ||||
Ovarian Infertility Genes | ||||
Metabolism of steroid hormones and vitamin D | ||||
FSH signaling pathway | ||||
Integrated Breast Cancer Pathway | ||||
Phase 1 - Functionalization of compounds | ||||
Prostaglandin Synthesis and Regulation | ||||
Arachidonic acid metabolism | ||||
Eicosanoid Synthesis |
References | Top | |||
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REF 1 | 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. | |||
REF 2 | Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. |
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